GAST and intraepithelial neoplasia: It has been observed that there is no significant increase in the risk of colon adenoma and CRC development with long-term use of PPIs or in hypergastrinemia conditions such as Zolinger-Ellison syndrome.[15] In the study of Robertson et al[14] in the USA, no relationship was found between colorectal adenomas and gastrin levels.[11] In a study designed in Germany in 377 patients aged 50 years and older, H pylori infection was found to be more common in patients with hyperplastic polyps and low-grade intraepithelial neoplasia.