MAP1LC3B is one of the crucial autophagy-related proteins and its lipidated form is considered a biomarker for the autophagosomes.[29,30] MAP1LC3B exerts its effects mainly by interacting with sequestosome 1, a substrate for mitophagy that transports the cargo into the autophagosomes for degradation.[31] Various studies have investigated the core roles of MAP1LC3B in different diseases such as hepatitis C virus infection,[32] oral squamous cell carcinoma,[33] and Hermansky-Pudlak syndrome[34]; thus, it is considered a potential diagnostic and prognostic biomarker for a variety of patients. This evidence concerns the gene MAP1LC3B and Hermansky-Pudlak syndrome.