The results indicate that ribosome, COVID-19, cell adhesion molecules, autoimmune thyroid disease, intestinal immune network for IgA production, and Th17 cell differentiation were enriched in the control group, while neutrophil extracellular trap formation, alcoholism, viral carcinogenesis, shigellosis, pathogenic Escherichia coli infection, leukocyte trans-endothelial migration, and p53 signaling pathway were enriched in patients with septic shock. Here, TP53 is linked to autoimmune thyroid disease.