ROBO3 and horizontal gaze palsy with progressive scoliosis: One study reported that a Serbian child had all clinical and neuroimaging characteristics of HGPPS; however, no ROBO3 mutation was found.[38] After DNA extraction and gene sequencing, Sami et al[39] discovered the effects of cytoplasmic domains C2 and C3 on the pathological appearance of HGPPS and emphasized that inbreeding increased the risk of disease.