CCL2 and renal fibrosis: However, the results were surprising: there was no significant reduction in renal macrophages and no improvement in cystic lesions or renal function, but genetic knockout of MCP-1 prevented pulmonary edema in mice with congenital polycystic kidneys and increased survival in mice.[70] The results of inhibition of MCP-1/CCR2 axis in treating renal fibrosis are not completely consistent, and the reasons for this are still unclear.