CCL2 and chronic kidney disease: Inflammation is a critical factor that drives renal fibrosis, and continuous inflammatory stimulation is an important pathogenesis of CKD.[42] Numerous reports demonstrated that MCP-1/CCR2 axis plays a vital role in macrophage chemotaxis during both the occurrence and development of inflammation.[43] The MCP-1/CCR2 axis are related to inflammation and progression of kidney fibrosis.