CCL2 and Nephropathy: Compared with wild-type mice, CCR2-deficient mice showed significant improvement in renal fibrosis, indicating that the MCP-1/CCR2 axis mediated the progression of renal fibrosis in the doxorubicin-induced nephropathy model.[49] Kashyap et al performed renal artery stenosis surgery on wild-type and MCP-1 knockout mice to form a mouse model of renal vascular hypertension.