CCR2 and renal fibrosis: Xu et al blocked CCR2 in unilateral renal ischemia/reperfusion injury (U-IRI) mice by genetic engineering or the drug RS102895 and found a decrease in macrophages, T cells, and dendritic cells in damaged kidneys and reduced fibrosis and inflammation.[28] Similarly, the CCR2 antagonist RS102895 can improve renal fibrosis in U-IRI mice and IgA nephropathy.[45,64]