The TME is important in HCC development and therapeutic response, wherein cancer cells interact with multiple immune components to form a suppressive immune microenvironment that promotes immune escape, proliferation, invasion, and metastasis of HCC cells and that mediates drug resistance.[26] We identified a correlation between DHRS1 gene copy number and infiltrating immune cells in pan-cancer via the TIMER database and demonstrated that the abundance of most immune subsets changed with the levels of DHRS1 mRNA using the TISIDB online tool. Here, DHRS1 is linked to cancer.