DHRS1 and hepatocellular carcinoma: The TME is important in HCC development and therapeutic response, wherein cancer cells interact with multiple immune components to form a suppressive immune microenvironment that promotes immune escape, proliferation, invasion, and metastasis of HCC cells and that mediates drug resistance.[26] We identified a correlation between DHRS1 gene copy number and infiltrating immune cells in pan-cancer via the TIMER database and demonstrated that the abundance of most immune subsets changed with the levels of DHRS1 mRNA using the TISIDB online tool.