In response to retinal ischemia and hypoxia, a large amount of vascular endothelial growth factor (VEGF) is produced, which promotes neovascularization and formation of neovascularization membrane in the fundus, iris, and anterior chamber angle.[2,4,6] This fibrous membrane gradually blocks the anterior chamber angle, resulting in adhesion of the iris and trabecular network, closure of the anterior chamber angle, and accordingly, increased intraocular pressure (IOP). The gene discussed is VEGFA; the disease is retinal ischemia.