TP53 and hereditary clear cell renal cell carcinoma: TP53 gene, also known as p53, is an important tumor suppressor gene, which can activate p21, Bax and other downstream target genes to interfere with cell cycle, apoptosis, etc., and then inhibit the development of cancer.[52] However, in almost all renal cell carcinomas, p53 exists as wild-type, and its signal pathway will lose its anticancer function due to tissue or disease specificity.