There are future perspectives on the exploitation of this lymphocyte tumor infiltrate for the application of immunotherapies.[52] Currently, the prognostic and predictive aspect of the tumor microclimate is being studied to apply therapies with Programmed cell death ligand 1 inhibitors.[52,53] In the case of benign tumors, inflammation appears to play a crucial role in the development of tumors and can continue to exist throughout the growth process due to its ability to promote cell proliferation.[54]. Here, CD274 is linked to benign neoplasm.