Knockdown of PTEN has a protective effect on hypoxia-reoxygenation-induced hippocampal neurons, and its mechanism of action may be achieved by negatively regulating AKT signaling.[86] In addition, the excitotoxic stimulation of NMDA can cause the translocation of PTEN nuclei in neurons, and it was found that the application of Tat-K13 interfering peptide not only reduced the ischemia-induced translocation of PTEN nuclei but also effectively reduced the ischemic brain injury at 6 hours after stroke in a focal ischemic rat model.[87]. Here, PTEN is linked to stroke disorder.