After adjusting for age, gender, T.Bil, ALP, Sp100, and gp210, IIF-AMA (OR: 3.05, 95% CI: 1.59–5.87), AMA-M2 (OR: 3.11, 95% CI: 1.61–6.01), and M2-3E (OR: 3.29, 95% CI: 1.63–6.66) remained significantly associated with an increased liver cirrhosis incidence. The gene discussed is SP100; the disease is cirrhosis of liver.