Furthermore, cellular studies revealed that triptolide, which had high binding ability to IFN-γ and IL-2 according to our molecular docking analysis, could inhibit IFN-γ signal transduction[38] and T cell IL-2 production.[39] Thus, the regulation of inflammatory cytokines may play a significant role in bioactive ingredients of TWH against BD. This evidence concerns the gene IFNG and Behcet disease.