PTGS2, also known as cyclooxygenase 2 (COX2), is an inducible enzyme which is involved in prostaglandin biosynthesis during the immune response to inflammation.[40] COX2 activity was found to be significantly increased in neutrophils obtained from patients with BD[41] and nonsteroidal anti-inflammatory drugs (NSAIDS), which are COX inhibitors, are commonly used to treat joint pains in patients with BD. The gene discussed is PTGS2; the disease is Behcet disease.