Serum ROS levels were higher in patients with BD than in healthy controls, and neutrophils from patients with BD produced more ROS.[48] According to a cross-sectional study, enhanced activities of ROS-producing enzymes such as NADPH oxidase, myeloperoxidase and COX2 have been detected in patients with BD.[41] Moreover, nitric oxide, another important source of oxidative stress, was also found to be increased in BD patients.[16,49] NOS2, also named inducible nitric oxide synthase (iNOS), was identified as a core target in our study. This evidence concerns the gene PTGS2 and Behcet disease.