After entering the nucleus, it can bind to transcription factor TCF, increase the transcription of target genes c-MYC, snail, and cyclin D1 (CCND1), and promote liver cancer cell proliferation and epithelial-mesenchymal transition (EMT).[18] Yang W et al[19] first found that EGFR could promote PKM2 nuclear entry in glioma cells. This evidence concerns the gene CCND1 and central nervous system cancer.