MiR-4417 and miR-372 can also enhance PKM2’s non-metabolic enzyme function involved in HCC occurrence.[54,55] MiR-4417 inhibits tripartite motif containing 35 expression, increases PKM2 phosphorylation at Tyr-105, promotes liver cancer cell proliferation, and inhibits apoptosis.[54] But how PKM2 Tyr-105 phosphorylation affects liver cancer cell proliferation and apoptosis remains to be further studied. The gene discussed is PKM; the disease is liver cancer.