Although there are reports that nuclear PKM2 can promote octamer-binding transcription factor-4 transactivation, which plays an important role in maintaining pancreatic cancer cell stemness,[32] whether PKM2 can also affect octamer-binding transcription factor-4 transactivation in liver cancer cells, affecting liver cancer cell stemness, has not been reported. The gene discussed is TCF4; the disease is familial pancreatic carcinoma.