STAT3 and hepatocellular carcinoma: In addition, it is also related to PKM2 promoting STAT3 phosphorylation and increasing the expression of downstream genes related to tumor proliferation, apoptosis, and migration.[51] The above studies suggest that multiple lncRNAs can promote PKM2 expression or nuclear translocation and enhance its non-metabolic enzyme function involved in HCC tumorigenesis and development, providing new research ideas for HCC prevention and treatment.