Liu WR et al[15] found that knocking down PKM2 in highly metastatic liver cancer cells HCCLM3 could reduce the expression of HIF-1α protein and the phosphorylation of AKT and JUK, while reducing liver cancer cell angiogenesis ability, reducing the number of tubules, number of tubules branching points, and tubule length. This evidence concerns the gene HIF1A and liver cancer.