PKM and liver cancer: Further studies have found that ARHGAP24 binds to PKM2 and recruits a new E3 ubiquitin ligase WWP1, promoting PKM2 degradation, thus inhibiting PKM2-mediated β-catenin transactivation, inhibiting liver cancer cell proliferation, migration, and other biological functions.[4] This suggests that the ARHGAP24/WWP1/PKM2/β-catenin axis can inhibit HCC tumorigenesis and development and can be used as a new approach for treating HCC.