PKM and cancer: Furthermore, recent research reported that the recruitment of HIF-1α and p300 mediated by nuclear PKM2 under hypoxia in breast cancer cells also caused the upregulation of 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 3 a glycolytic enzyme and positively associated with cancer progression and aggression).[17] These studies suggest that nuclear PKM2 can promote glycolysis by activating HIF-1α, potentially playing a role in various biological functions of HCC.