PKM and liver cancer: Niu J et al[6] further found that EGF treatment increased the expressions of DKK1 mRNA and protein in liver cancer cells, and through gene knockout and phosphorylation site mutation experiments, they found that EGF-activated EGFR can induce PKM2 Ser37 residue phosphorylation and p300 Ser1834 residue phosphorylation through extracellular regulated protein kinases signaling pathway and PI3K-AKT signaling pathway respectively.