Long noncoding RNA (lncRNA), circular RNA (circRNA) and microRNA targeting PKM2 to affect HCC tumorigenesis and development are one of the current research hotspots.[36,45] noncoding RNA can target PKM2’s metabolic enzyme function to affect liver cancer cell metabolic reprogramming,[46–48] but also target PKM2’s non-metabolic enzyme function to affect HCC tumorigenesis and development.[49,50]. Here, PKM is linked to liver cancer.