The earliest study found that nuclear PKM2 promoted histone H3 Thr11 phosphorylation in glioma cells, eliminating histone deacetylases 3 transcriptional inhibition of CCND1 and MYC genes, thereby increasing their expression and affecting tumor progression.[29] But whether this reaction is also in HCC has not been reported. Here, CCND1 is linked to central nervous system cancer.