Some studies have suggested that the reason for the prevalence in blood pressure with high BMI may be related to a high insulin state, which activates the sympathetic nervous system, leading to increased renal reabsorption of sodium, increased vascular volume, vascular constriction, ultimately leading to hypertension.[34] Other studies have suggested that excessive or abnormal distribution of adipose tissue in obese individuals can affect the renin-angiotensin-aldosterone system, leading to an increase in blood pressure.[35]. The gene discussed is INS; the disease is Hypertension.