BALADs frequently contain scattered hyper-reflective particles, are piriform or dome-shaped, and have an outer border that is hyper-reflective and continuous with the EZ layer.[27,29] In addition, ORTs are seldom foveal, whereas BALADS are commonly foveal or parafoveal.[30] ORTs are non-exudative and resistant to anti-VEGF treatment, which is another key difference between bacillary detachments and ORTs.[27] Cystoid macular edema is characterized by IRF retention in well-defined regions. The gene discussed is VEGFA; the disease is cystoid macular edema.