IL17A and infection: In psoriasis, triggering factors like trauma and infection could stimulate IL-23 production and consequently induce Th17 cells to produce pro-inflammatory cell cytokines like IL-17, which could in turn amplify the inflammatory cascade response and exacerbate skin inflammation.[13] Furthermore, there are also interactions between IL-23/Il-17 axis and PCD signaling pathways, which could ultimately induce PANoptosis and strong inflammatory response.