The principal function of these granzymes is to induce target cell death like apoptosis or pyroptosis.[49] Recent studies have shown that granzyme plays a pro-inflammatory role in psoriasis and that its expression is synergistically elevated with that of IL-23/IL-17-related genes.[50] To sum up, the discovery of these genes adds to our understanding of the etiology and pathogenesis of psoriasis, as well as the role of PANoptosis for immune contexture of psoriasis. The gene discussed is IL17A; the disease is psoriasis.