RIPK1 and psoriasis: In psoriasis lesions, the expression of necroptosis-related molecules like RIPK1 and RIPK3 was significantly increased, and the activation of necroptosis mediated by RIPK1/RIPK3 pathway showed a significant effect on the upregulation of IL-17 and could subsequently induce chronic inflammation in psoriasis.[10] IL-23/IL-17 axis is also closely related to the PANoptosome complex.