Upon stimulated with PANoptosome, CASP1 could induce the production of inflammatory cytokines of IL-1β and IL-18 that may directly facilitate the production of IL-17 and amplifies the inflammatory response of psoriasis.[48] Granzyme B (GzmB) and granzyme A (GzmA) are 2 main subtypes of granzymes. The gene discussed is GZMB; the disease is psoriasis.