PRMT5 and cancer: To broadly evaluate a connection between PRMT5 and DDR pathway regulation in clinically relevant tumor types, we first evaluated the correlation of PRMT5 mRNA expression with that of 235 genes associated with DNA replication and repair across 188 cancer cell lines (61 breast, 64 ovarian, 11 prostate, and 52 pancreatic cancer cell lines) from the Cancer Cell Line Encyclopedia (CCLE) database (33).