PRMT5 expression was moderately to strongly correlated (Pearson score ≥ 0.4) with established DDR genes such as BRCA1, BRCA2, RAD51, RAD51D, RAD51AP1, FANCA, and FANCI across 125 ovarian and breast cancer cell lines (Fig. 1B). This evidence concerns the gene FANCA and breast carcinoma.