Interestingly, POLD1 intron retention did not reach significance, although previous works have linked AS of this to serine and arginine rich splicing factor 1 (SRSF1; ref. 18), and preliminary reports highlight PRMT5 inhibition induced POLD1 intron retention in other datasets (uveal melanoma; refs. 18, 36). Here, SRSF1 is linked to uveal melanoma.