As a common switch for autophagy and metabolic reprogramming, PTEN achieves tumor suppression and immune protection by blocking mTOR signaling, inducing T‐cell infiltration, inhibiting M2 macrophage polarization, and decreasing PD‐L1 expression in the TME,159, 160, 161 suggesting that PTEN is a promising therapeutic target to enhance antitumor immunity. This evidence concerns the gene CD274 and neoplasm.