CD8A and neoplasm: first explicitly reported the phenomenon of crosstalk between the ferroptosis pathway of immune cells and tumor cells; immune‐activated CD8+ T cells downregulate the expression of glutamate‐cystine anti‐transport system proteins (SLC3A2 and SLC7A11) by releasing IFN‐γ, inhibiting the uptake of cystine by tumor cells, and promoting tumor cell lipid peroxidation and ferroptosis, resulting in enhanced antitumor immunity.