Li et al24 confirmed that 100A2 induces glycolysis reprogramming through the upregulation of glucose transporter-1 (GLUT1) expression via the phosphoinositide 3 kinase/Protein Kinase B (PI3K/AKT) pathway, thus driving cell proliferation and progression in colorectal cancer. The gene discussed is SLC2A1; the disease is colorectal cancer.