PKM and colorectal carcinoma: Additionally, glycolysis influences cancer cell drug resistance, and drug-resistant cells are more glycolytic and produce more adenosine-triphosphate (ATP).25 Artesunate (ART) enhances adriamycin (ADR) toxicity by suppressing glycolysis, mdr1/abcg2 level in K562/ADR cells.26 Wang et al25 ascertained that exosomes originating from CRC cells resistant to oxaliplatin transfer ciRS-122 to sensitive cells and enhance glycolysis by increasing the PKM2 expression to enhance oxaliplatin resistance.