Actors of Notch signaling, such as Notch receptors (NOTCH1, -2, -3 and −4), Notch ligands (JAG1 and -2, Dll-1, -3 and4), as well as Notch pathway targets (HES and HEY effector proteins) are aberrantly overexpressed in colorectal tumors. This evidence concerns the gene JAG1 and colorectal neoplasm.