Colorectal DTP cells express the genes LGR5 and MEX3A, represent a small subpopulation of the parental tumor (0.3%–5%), are chemoresistant and regenerate after therapeutic treatment (Álvarez-Varela et al., 2022) (Sharma et al., 2010; Liau et al., 2017) (Figure 2). Here, LGR5 is linked to neoplasm.