APC and colorectal carcinoma: Colorectal carcinoma emerging from the conventional carcinogenesis pathway are often driven by activating mutations of genes controlling the Wnt signaling pathway, most frequently through bi-allelic inactivation of the adenomatous polyposis coli (APC) tumor suppressor gene, leading to aberrant Wnt pathway activation (Jen et al., 1994; Näthke, 2004).