LGR5 and neoplasm: This re-expression of Lgr5 by non-CSCs seemed to occur independently of microenvironmental factors and was necessary for metastasis, but dispensable for primary tumor establishment, highlighting the key role of CSC-heterogeneity in important events like metastasis and how the dedifferentiation of non-CSC cells may contribute to this phenomenon (Fumagalli et al., 2020).