DLL4 and colorectal cancer: In addition to JAG1 and DLL4, the JAG2/NOTCH pathway also exerts a cancer-promoting effect in colorectal cancer cells, as JAG2 knockdown in colorectal cancer cells inhibits their expression of CD133, decreasing in a similar manner their ability to form spheroids and to induce metastasis (Table 1) (Huang et al., 2017).