Moreover, the expression of NOTCH1, -3 and -4 receptors was reported to be significantly higher in colorectal cancers compared to normal and adenoma tissues (Zheng et al., 2015), and patients overexpressing NOTCH3 and NOTCH4 receptors, and the HEY1 transcriptional target, exhibit poorer overall survival (Rallis et al., 2019; Shaik et al., 2020). This evidence concerns the gene NOTCH3 and colorectal cancer.