This analogous effect of NOTCH1 and -2 has also been found in tumors from Familial Adenomatous Polyposis (FAP) patients (Rodilla et al., 2009) and might be representative of the behavior of these receptors in the conventional adenoma-carcinoma pathway according to several in vitro studies (Guilmeau et al., 2010). This evidence concerns the gene NOTCH1 and Familial adenomatous polyposis.