Besides, it has been shown that the Bone Morphogenetic Protein (BMP) non-canonical activation of NOTCH1 pathway was participating in epithelial-to-mesenchymal transition (EMT) and led to poorer prognosis in mesenchymal-subtype of colorectal cancer (Irshad et al., 2017), a subtype featuring EMT and MSI high signatures (Kim et al., 2021; Singh et al., 2021). Here, NOTCH1 is linked to colorectal cancer.