Consistent with methylated bovine serum albumin (mBSA)/GM-CSF arthritis, mice undergoing zymosan-induced arthritis and receiving Dex treatment exhibited less pain-like behavior compared to those that were given the control saline (Figure 4D); histological analyses of the joints indicated that the zymosan-induced arthritis was also inhibited following Dex treatment (Figure 4E). This evidence concerns the gene CSF2 and arthritic joint disease.