P2RX4 and neuropathy: Interestingly, P2X4 antagonist injection in P2X4KI mice of both sexes not only reversed the hypersensitivity induced by neuropathy (Figure 1C) but also the basal hypersensitivity of naive P2X4KI mice, restoring the mechanical threshold in males and females to levels close to those measured in WT mice (Figures 1C and S4).