Previous studies have found that the cardiac macrophages, as one of the important immune regulatory cells, are of great significance in the occurrence and development of MI [34], the NLRP3 inflammasome plays an important role in myocardial injury after MI [35], and IL-1β can promote the polarization and maturation of M1 macrophages and inflammatory response by activating downstream signaling cascade responses, while M2 macrophages suppress the inflammatory response by secreting anti-inflammatory cytokines, promote tissue phagocytosis, repair, and ameliorate myocardial injury after MI [36,37]. This evidence concerns the gene NLRP3 and myocardial infarction.