SOD1 and amyotrophic lateral sclerosis: SOD1 was the first gene in which its mutations were identified in ALS over 30 years ago, predicting it to be a causative factor in motor neuron degeneration.5 A hallmark of SOD1-associated ALS is the misfolding and aggregation of SOD1 into neurotoxic species induced by gene mutations.6 The disease mechanism in which this occurs remains unknown.6 Mechanistic studies would be greatly facilitated with the availability of high-quality antibodies.