PSMB8 is the catalytic subunit of the immunoproteasome and is implicated in glioblastoma, mucinous ovarian cancer, cutaneous squamous cell carcinoma, papillary thyroid carcinoma, and prostate cancer development and progression (50–52), consistent with our findings showing that PSMB8 was associated with high immune infiltration and was a predictive protective gene. This evidence concerns the gene PSMB8 and Familial prostate cancer.