In this study, we selected 14 TME-related genes, including BIRC3, CELSR2, CXCL14, IL18, KLRB1, NPY1R, PSMB8, SCUBE2, STC2, CD1C, HLA-DPB1, GIMAP2, IRF1 and TNFAIP8, all of which were implicated in tumor progression and prognosis outcomes. This evidence concerns the gene SCUBE2 and neoplasm.