PCSK9 and neoplasm: The results indicated that PCSK9 was associated with a detrimental prognosis with five patient or tumor characteristics: female (OS: p = 0.01; PFS: p = 0.02), Asian race [OS: p = 0.01; PFS: p = 0.01], no hepatitis virus infection [OS: p = 0.03; PFS: p = 0.02], pathology stage 2 [OS: p = 0.01] and stage 3 [OS: p = 0.04], grade 2 [OS: p = 0.01], and AJCC stage 2 (OS: p = 0.01) and stage 3 (PFS: p = 0.03) (Figure 4A).