Among them, PCSK9 showed a detrimental relationship in three cancer types, including colorectal cancer [OS: total = 177, HR = 1.46, Cox p = 0.048], lung cancer [OS: total = 56, HR = 1.43 Cox p = 0.028], lung cancer [RFS: total = 56, HR = 1.30, Cox p = 0.011] and head and neck cancer [RFS: total = 28, HR = 3.26, Cox p = 0.048]. The gene discussed is PCSK9; the disease is head and neck cancer.