We future searched the cBioPortal website for PCSK9-related tumor gene mutations and identified six types of tumors with a total of eleven protein changes: Melanoma (D321N, E84K, G176E, E405K, S249G), Uterine Endometrioid Carcinoma (V79M), Colorectal Adenocarcinoma (R272L), Diffuse Large B-Cell Lymphoma (Q454H), Serous Ovarian Cancer (R93H, S5G), and Esophageal Adenocarcinoma (C526F). This evidence concerns the gene PCSK9 and melanoma.