The correlations between 46 immune checkpoint genes and PCSK9 protein expression levels were calculated, and a significant relationship was found in many cancer types with many of the 46 genes, such as THCA (40 of 46), BRCA (37 of 46), LUAD (37 of 46), BLCA (35 of 46), and TGCT (33 of 46) (Figure 8B). This evidence concerns the gene PCSK9 and cancer.