Th1 type cellular immune response mainly involves generating IFN-γ producing T-cell populations, antigen-specific cytotoxic CD8+ T-cells, and a high titer of IgG2a is reported to confer protection in brucellosis (Golding et al., 2001; Yingst and Hoover, 2003; Skendros et al., 2011; Vitry et al., 2014). Here, CD8A is linked to brucellosis.