Changes in the hypermethylation status of the CpG islets of the laminin A/C (LMNA) gene are associated with insulin resistance in patients with polycystic ovary syndrome (PCOS), suggesting that this gene may be involved in the regulation of PCOS-associated insulin resistance (Ting et al., 2013). The gene discussed is LMNA; the disease is polycystic ovary syndrome.