LMNA and Insulin resistance: In addition, insulin resistance is an important pathological mechanism in endometrial cancer and EM (Wei and Li, 2020), and mutations in LMNA are thought to be a causal factor in non-valvular atrial fibrillation (NVAF) (Saj et al., 2012) and Hutchinson–Gilford premature senescence syndrome (HGPS) (Auld et al., 2010).