ENO2 and neoplasm: To our surprise, some traditional tumor markers, such as serum CYFRA21-1(OR 1.53, P <0.001), ProGRP (OR 1.08, P =0.01), SCC (OR 1.54, P =0.01) and NSE (OR 1.07, P =0.02) were significantly increased in severe patients (Table 4).