His plasma anti-IFN-γ autoantibodies level was positive with a high titer at 1:2500↑.<h4>Intervention</h4>The patient went through atrial fibrillation at the first dose of amphotericin B liposomes and treated with voriconazole later.<h4>Outcomes</h4>His fever, cough and dyspnea quickly disappeared since the fourth day of treatment. Here, IFNG is linked to atrial fibrillation.