Immunosuppression has also been observed in symptomatic patients during later stages of infection, which can be correlated with the presence of IL-10 produced in response to IFN-γ (Shahriar et al., 1999; Varma and Naseem, 2010; Fampa et al., 2021; Patel et al., 2021) Kumar and colleagues (2018) investigated the relationship between parasite load as a marker of disease severity and T cell function in bone marrow (Kumar et al., 2007; Kumar et al., 2018). This evidence concerns the gene IFNG and infection.