Exogenous IL-27 administration for Staphylococcus aureus-infected osteomyelitis not only induces accumulation of pro-inflammatory IL-17-producing RORγt+ neutrophils, leading to reduced abscess formation, but also inhibits RANKL-induced osteoclast activation to relieve osteomyelitis osteolysis (152). Here, IL27 is linked to osteomyelitis.