The hybrid nanoparticles that release PS and glucocorticoid-induced tumor necrosis factor receptor family-related protein, or poly (lactic-co-glycolic acid) (GITR-PLGA), utilize the immune activating role of PDT and GITR-PLGA-mediated suppression of immunosuppression to increase the amount of anti-tumor CD8+ T cells in the tumor (16). The gene discussed is CD8A; the disease is neoplasm.