Elevated levels of inflammatory cytokines such as interleukin-1 (IL-1) and IL-17 in BD have been found to be associated with the aberrant expression of miRNAs, such as miRNA-155, which regulates the Th17 immune response by targeting Ets-1 in BD, and miR-155 and IL-17 expression are significantly increased in CD4+ T cells from patients with active BD. Here, CD4 is linked to Behcet disease.