ACOSOG Z1072 was followed by the non-resection trial called “Cryoablation of Low-Risk Small Breast Cancer (ICE3)”, evaluating the recurrence rate and efficacy of cryoablation without lumpectomy in 208 woman women with low-risk breast cancer (hormone receptor positive, HER2-) (10). The gene discussed is ERBB2; the disease is breast carcinoma.