According to the European League Against Rheumatism (EULAR) and the American College of Rheumatology (ACR), the classification criteria for SLE consist of a mandatory entry criterion of positive anti-nuclear antibodies (ANAs) at least once, followed by additive weighted criteria grouped into seven clinical domains, namely, constitutional, hematologic, neuropsychiatric, mucocutaneous, serosal, musculoskeletal, and renal, and three immunological domains: antiphospholipid antibodies (aPLs), complement proteins, and SLE-specific antibodies (16). The gene discussed is VTN; the disease is systemic lupus erythematosus.