Approximately 66% of all patients living with Alzheimer disease (AD) in the United States (34) are women, who also have greater overall lifetime risk (35), experience higher disease burden, including increased AD biomarkers (tau) in the medial temporal lobe (36, 37), and among those with another AD biomarker (beta amyloid), experience more rapid cognitive decline (38). Here, MAPT is linked to Alzheimer disease.