•Reduced allergy clinical symptom score and foot pad inflammation compared to SLIT alone•Increase antigen-specific IgG2a•Decrease serum IgG1:IgG2a ratio•Decrease antigen-specific IL-5 and IL-13•Increase antigen-specific IFNγ•Increase IFNγ+ cells in both CD4+ and CD8+ cells that transfer protection to other hypersensitive mice. Here, CD4 is linked to Allergy.