Silencing SOX2 suppresses the expression of drug resistance and anti-apoptotic genes and increases the sensitivity of the cells to radiation-combined-cisplatin chemo therapy [19]. According to Grubelnik et al. Nanog and OCT4 genes were overexpressed in cancers with lymph node metastasis compared to cases without metastases [44]. The gene discussed is POU5F1; the disease is cancer.