GLP-1 RA significantly reduces the risk of total stroke (RR: 0.83; 95%CI: 0.73-0.95; P = 0.005), as well as ischemic stroke (RR: 0.83; 95%CI: 0.73-0.95; P = 0.008) in type 2 diabetes with cardiovascular risk factors. The gene discussed is GCG; the disease is type 2 diabetes mellitus.