The query term was “type one diabetes mellitus” OR “insulin dependent diabetes mellitus” OR “diabetes mellitus”; “linear growth” OR “linear height”; “insulin therapy” OR “treatment modalities.” The inclusion criteria involve articles with studies conducted exclusively on T1DM, autoimmune T1DM, the effects of it on linear growth, and insulin therapy; studies conducted preceding 10 years are also included. This evidence concerns the gene INS and type 1 diabetes mellitus.