Other factors such as plasminogen activator inhibitor-1 (PAI-1) are also associated with components of MetS, such as hypertriglyceridemia, hyperinsulinemia, and obesity, thus leading to high recurrence rates of AMI in the Arabic population, as seen by Abu-Farha et al. In contrast, adiponectin is a cardioprotective cytokine and is known to be associated with a lower risk of multiple disorders, including CAD, AMI, and hypertension [11]. This evidence concerns the gene SERPINE1 and obesity due to melanocortin 4 receptor deficiency.