For example, the study of Yu et al 9 has indicated that the highly expression of miR-21-5p promotes the proliferation and invasion of colon carcinoma cells by targeting CHL1.The study results of Pan et al 10 have shown that miR-1245a promotes the proliferation and invasion of colon carcinoma by targeting BRCA2. The gene discussed is CHL1; the disease is colon carcinoma.