Similarly, we observed a similar phenomenon in mifepristone-induced apoptotic HCC cells, indicating a dual effect of mifepristone: ΔΨm loss leading to the leakage of HSP60 into the cytosol and an increase in the formation of the GR-HSP60-survivin complex, ultimately leading to survivin degradation. The gene discussed is BIRC5; the disease is hepatocellular carcinoma.