Previous studies have shown that low expression levels of LKB1 and high expression levels of VEGFR2 may indicate a poor prognosis in patients with LUAD 14, 15, and the loss of expression of p16 and Smad4 in patients with LUAD is related to malignant biological behavior of the tumor and poor prognosis 16. This evidence concerns the gene SMAD4 and neoplasm.