DVL3 and metastatic malignant neoplasm in the lymph nodes: Furthermore, in the entire cohort of 626 patients, the protein expression levels of DVL3 were strongly associated with the presence of lymph node metastasis and TNM stage (Table 3, all P<0.001); the expression level of DVL3 was higher in patients with lymph node metastasis than in nonmetastatic patients and in patients with stage III/IV disease than in patients with stage I/II disease.