Our study showed that the expression level of DVL3 was significantly higher in PDGN-LUAD tumor tissue than in normal lung tissue, and the abnormal expression of DVL3 was strongly associated with the OS of PDGN-LUAD patients, who could be classified into high-risk and low-risk groups based on their tumor protein expression level of DVL3. The gene discussed is DVL3; the disease is neoplasm.