We used GEPIA database to analyze the expression of different TFAP2 family proteins in bladder cancer patients, and found that the expression of TFAP2A, TFAP2B, TFAP2C and TFAP2E in bladder cancer tissues was higher than that in adjacent tissues, although only the expression of TFAP2A was statistically significant (Figure 1a). The gene discussed is TFAP2C; the disease is urinary bladder cancer.