In this research, the bulk RNA-seq data from the Cancer Genome Atlas (TCGA) database was utilized to explore the correlation between FMNL1 and features of TME, and FMNL1 was found to be tightly correlated with features of TME in not only hepatocellular carcinoma (HCC) but also multiple cancer types. This evidence concerns the gene FMNL1 and hepatocellular carcinoma.