SIGLEC15 and colon adenocarcinoma: The univariate Cox regression analyses of patients revealed that age (HR=1.947, 95% CI: 1.152 to 3.291, p<0.01), TNM stage (HR=2.910, 95% CI: 1.746 to 4.850, p<0.001), PD-L1(SA) (HR=0.493, 95% CI: 0.278 to 0.874, p=0.015) and Siglec15(SA) (HR=2.481, 95% CI: 1.450 to 4.245, p<0.01) expression were associated with prognosis of COAD patients in terms of OS (Table 2).