Multivariate Cox regression analysis indicated that only TNM stage (HR=3.059, 95% CI: 1.799 to 5.200, p<0.001), PD-L1(SA) (HR=0.352, 95% CI: 0.193 to 0.642, p=0.001) and Siglec15(SA) (HR=3.264, 95% CI: 1.808 to 5.890, p<0.001) expression were independent prognostic factors for OS in COAD patients, but not Siglec15(whole) and Siglec15(TA) (Table 2). This evidence concerns the gene CD274 and colon adenocarcinoma.