First, the analysis of GEO databases (GSE15471, GSE16515) and IHC staining results of PDAC patients' tissue indicated that the level of DVL2 was elevated in pancreatic cancer (GSE15471, p < 0.0001, GSE16515, p = 0.0205) (Figure 4A and B). Here, DVL2 is linked to familial pancreatic carcinoma.