5. Lin et al. reported that COL1A2 is upregulated in HSCC compared to normal controls; they also reported that a high COL1A2 expression level predicted a high locoregional recurrence rate and a less favorable disease-free survival rate 6. A recent study was observed by Kim EK et al. that FGFR1 expansion is an independent prognostic factor for hypopharyngeal and laryngeal squamous cell carcinoma 7. The gene discussed is COL1A2; the disease is laryngeal squamous cell carcinoma.