The identified PPVs are associated with the development of coronary heart disease (ACE, THBD, LDLR, etc.), ischemic stroke (F5, GP1BA), Alzheimer's (APOE, CD33, TREM2, SORL1), neonatal conditions(SFTPA1, SFTPA2, SFTPB, SFTPD), lung cancer (SEMA3B, WNT5B, RECK), respiratory infection (ADAM33, CCL1, CXCL1, MUC1), diabetes mellitus (INS, EGFL8, KIR3DL1), diarrheal diseases (LTF, UGT1A7, UGT1A8, UGT1A9, UGT2B7), and kidney disease (ACE, AGT, PXDN, COLEC11). The gene discussed is RECK; the disease is ischemic stroke.