Indeed, a group of 38 small proteins, including HCRT (narcolepsy, rs1327645071), CCL2 (neural tube defects and HIV, rs898151976), CCL7 (nephrogenic systemic fibrosis and toxic black mold infections, rs1439804640), CCL8 (tenosynovitis and T-Cell non-Hodgkin Lymphoma), INSL5 (Cryptorchidism, rs751653318), IGF1 (Pituitary Gland Disease, rs3730195), GYPA (malaria susceptibility, rs371519566) and others showed gene variants affecting the N-region charge. This evidence concerns the gene HCRT and pituitary gland disorder.